University of Giessen Lung Center

Publications

The following is a complete list of publications from the Morty Laboratory:

• Wesch D, Miranda P, Afonso-Oramas D, Althaus M, Castro-Hernández J, Domínguez J, Morty RE, Clauss W, González-Hernández T, Alvarez de la Rosa D, Giraldez T. The neuronal-specific SGK1.1 kinase regulates ? epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling. Am J Physiol Cell Physiol. in press. Download PDF version
• Hecker M, Zaslona Z, Kwapiszewska G, Zakrzewicz A, Wilhelm J, Marsh LM, Sedding D, Klepetko W, Lohmeyer J, Seeger W, Weissmann N, Schermuly RT, Eickelberg O, Morty RE. Dysregulation of the interleukin 13 receptor system: a novel pathomechanism in pulmonary arterial hypertension. Am J Respir Crit Care Med. in press. Download PDF version
• Althaus M, Pichl A, Clauss WG, Fronius M, Morty RE. Nitric oxide decreases Na+ absorption in H441 cells by inhibition of highly selective Na+ channels and Na+/K+-ATPase activity. Am J Respir Cell Mol. Biol. in press. Download PDF version
• Król M, Pawlowski KM, Skierski J, Turowski P, Majewska A, Polanska J, Ugorski M, Morty RE, Motyl T. Transcriptomic “portraits” of canine mammary cancer cell lines with various phenotypes. J Appl Genet. 2010;51(2):169-83, 2010. Download PDF version
• Król M, Polanska J, Pawlowski KM, Turowski P, Skierski J, Majewska A, Ugorski M, Morty RE, Motyl T. Transcriptomic signature of cell lines isolated from canine adenocarcinoma metastases to lungs. J Appl Genet. 51(1):37-50, 2010. Download PDF version
• Fronius M, Bogdan R, Althaus M, Morty RE, Clauss WG. Epithelial Na+ channels derived from human lung are activated by shear force. Respir Physiol Neurobiol. 170(1):113-119, 2010. Download PDF version
• Althaus M, Morty RE, Clauss W, Fronius M. 15 Jahre Kanalarbeit: der Epitheliale Natrium Kanal. Biol. Unserer Zeit. 5: 320-326, 2009. Download PDF version
• Morty RE, Königshoff M, Eickelberg O. Transforming growth factor-? signaling across ages: from distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc 6:607-613, 2009. Download PDF version
• Kumarasamy A, Schmitt I, Reiss I, van der Horst I, Dony E, Roberts JD, de Krijger RR, Tibboel D, Seeger W, Schermuly RT, Eickelberg O, Morty RE. Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs. Am J Respir Crit Care Med. 180: 1239-1252, 2009. Download PDF version
• Althaus M, Fronius M, Buchäckert Y, Vadász I, Clauss WG, Seeger W, Motterlini R, Morty RE. Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. Am J Respir Cell Mol Biol. 41(6):439-650, 2009. Download PDF version
• Tang B, Li Y, Nagaraj C, Morty RE, Gabor S, Stacher E, Voswinckel R, Weissmann N, Leithner K, Olschewski H, Olschewski A. Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 41(4):476-483, 2009. Download PDF version
• Wygrecka M, Marsh LM, Morty RE, Henneke I, Guenther A, Lohmeyer J, Markart P, Preissner KT. Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung. Blood. 113(22):5588-5598, 2009. Download PDF version
• Woyda K, Koebrich S, Reiss I, Rudloff S, Pullamsetti SS, Rühlmann A, Weissmann N, Ghofrani HA, Günther A, Seeger W, Grimminger F, Morty RE, Schermuly RT. Inhibition of PDE4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia. Eur Respir J. 32(4):871-880, 2009. Download PDF version
• Sevilla-Pérez J, Königshoff M, Kwapiszewska G, Amarie OV, Seeger W, Weissmann N, Schermuly RT, Morty RE, Eickelberg O. Shroom expression is attenuated in pulmonary arterial hypertension. Eur Respir J. 2(4):871-80, 2009. Download PDF version
• Vadász I, Schermuly RT, Ghofrani HA, Rummel S, Wehner S, Mühldorfer I, Schäfer KP, Seeger W, Morty RE, Grimminger F, Weissmann N. The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs. Crit Care Med. 36(5):1543-50, 2008. Download PDF version
• Alejandre-Alcázar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad GG, Tibboel D, Seeger W, Eickelberg O, Morty RE. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn. 237(1):259-69, 2008. Download PDF version
• Eickelberg O, Morty RE. Transforming growth factor beta/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited. Trends Cardiovasc Med. 17(8):263-9, 2007. Download PDF version
• Alejandre-Alcázar MA, Shalamanov PD, Amarie OV, Sevilla-Pérez J, Seeger W, Eickelberg O, Morty RE. Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development. Dev Dyn. 236(10):2825-35, 2007. Download PDF version
• Wygrecka M, Morty RE, Markart P, Kanse SM, Andreasen PA, Wind T, Guenther A, Preissner KT.Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome. J Biol Chem. 282(30):21671-82, 2007. Download PDF version
• Morty RE, Eickelberg O, Seeger W. Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies? Intensive Care Med. 33(7):1229-40, 2007. Download PDF version
• Zakrzewicz A, Hecker M, Marsh LM, Kwapiszewska G, Nejman B, Long L, Seeger W, Schermuly RT, Morrell NW, Morty RE, Eickelberg O. Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension. Circulation 12;115(23):2957-68, 2007. Download PDF version
• Sommer D, Bogdan R, Berger J, Peters DM, Morty RE, Clauss WG, Fronius M. CFTR-dependent Cl- secretion in Xenopus laevis lung epithelium. Respir Physiol Neurobiol. 158(1):97-106, 2007. Download PDF version 
• Zakrzewicz A, Kouri FM, Nejman B, Kwapiszewska G, Hecker M, Sandu R, Dony E, Seeger W, Schermuly RT, Eickelberg O, Morty RE. The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension. Eur Respir J. 29(6):1094-104, 2007. Download PDF version
• Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, Schermuly RT, Eickelberg O. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 27(5):1072-8, 2007. Download PDF version
• Alejandre-Alcázar MA, Kwapiszewska G, Reiss I, Amarie OV, Marsh LM, Sevilla-Pérez J, Wygrecka M, Eul B, Köbrich S, Hesse M, Schermuly RT, Seeger W, Eickelberg O, Morty RE. Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 292(2):L537-49, 2007. Download PDF version
• Krishnaveni MS, Hansen JL, Seeger W, Morty RE, Sheikh SP, Eickelberg O. Constitutive homo- and hetero-oligomerization of TbetaRII-B, an alternatively spliced variant of the mouse TGF-beta type II receptor. Biochem Biophys Res Commun. 351(3):651-7, 2006. Download PDF version
• Rea D, Hazell C, Andrews NW, Morty RE, Fülöp V. Expression, purification and preliminary crystallographic analysis of oligopeptidase B from Trypanosoma brucei. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62(Pt 8):808-10, 2006. Download PDF version
• Yildirim AO, Bulau P, Zakrzewicz D, Kitowska KE, Weissmann N, Grimminger F, Morty RE, Eickelberg O. Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am J Respir Cell Mol Biol. 35(4):436-43, 2006. Download PDF version 
• Olschewski A, Li Y, Tang B, Hanze J, Eul B, Bohle RM, Wilhelm J, Morty RE, Brau ME, Weir EK, Kwapiszewska G, Klepetko W, Seeger W, Olschewski H. Impact of TASK-1 in human pulmonary artery smooth muscle cells. Circ Res. 98(8):1072-80, 2006. Download PDF version
• Morty RE, Bulau P, Pellé R, Wilk S, Abe K. Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts. Biochem J. 394(Pt 3):635-45, 2006. Download PDF version
• Morty RE, Vadász I, Bulau P, Dive V, Oliveira V, Seeger W, Juliano L. Tropolysin, a new oligopeptidase from African trypanosomes. Biochemistry. 44(44):14658-69, 2005. Download PDF version
• Vadász I, Morty RE, Olschewski A, Königshoff M, Kohstall MG, Ghofrani HA, Grimminger F, Seeger W. Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase. Am J Respir Cell Mol Biol. 33(4):343-54, 2005. Download PDF version
• Morty RE, Shih AY, Fülöp V, Andrews NW. Identification of the reactive cysteine residues in oligopeptidase B from Trypanosoma brucei. FEBS Lett. 2005 Apr 11;579(10):2191-6. Download PDF version
• Morty RE, Pellé R, Vadász I, Uzcanga GL, Seeger W, Bubis J. Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts. J Biol Chem. 280(12):10925-37, 2005. Download PDF version
• Vadász I, Morty RE, Kohstall MG, Olschewski A, Grimminger F, Seeger W, Ghofrani HA. Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? Am J Respir Crit Care Med. 171(5):469-79, 2005. Download PDF version
• Morty RE, Burleigh BA. Oligopeptidase B. In: Handbook of Proteolytic Enzymes, 2nd edition (Barrett AJ, Rawlings ND & Woessner JF, editors) p.1900-1905, Elsevier, London, 2004.
• Hemerly JP, Oliveira V, Del Nery E, Morty RE, Andrews NW, Juliano MA, Juliano L. Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity. Biochem J. 373(Pt 3):933-9, 2003. Download PDF version
• Morty RE, Fülöp V, Andrews NW. Substrate recognition properties of oligopeptidase B from Salmonella enterica serovar Typhimurium. J Bacteriol. 184(12):3329-37, 2002. Download PDF version
• Morty RE, Morehead J. Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species. J Biol Chem. 277(29):26057-65, 2002. Download PDF version
• Morty RE, Lonsdale-Eccles JD, Mentele R, Auerswald EA, Coetzer TH. Trypanosome-derived oligopeptidase B is released into the plasma of infected rodents, where it persists and retains full catalytic activity. Infect Immun. 69(4):2757-61, 2001. Download PDF version
• Caler EV, Morty RE, Burleigh BA, Andrews NW. Dual role of signaling pathways leading to Ca(2+) and cyclic AMP elevation in host cell invasion by Trypanosoma cruzi. Infect Immun. 68(12):6602-10, 2001. Download PDF version
• Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei. Mol Med. 6(8):660-9, 2000. Download PDF version
• Morty RE, Troeberg L, Powers JC, Ono S, Lonsdale-Eccles JD, Coetzer TH. Characterisation of the antitrypanosomal activity of peptidyl alpha-aminoalkyl phosphonate diphenyl esters. Biochem Pharmacol. 60(10):1497-504, 2000. Download PDF version
• Morty RE, Authié E, Troeberg L, Lonsdale-Eccles JD, Coetzer TH. Purification and characterisation of a trypsin-like serine oligopeptidase from Trypanosoma congolense. Mol Biochem Parasitol. 102(1):145-55, 1999. Download PDF version
• Morty RE, Lonsdale-Eccles JD, Morehead J, Caler EV, Mentele R, Auerswald EA, Coetzer TH, Andrews NW, Burleigh BA. Oligopeptidase B from Trypanosoma brucei, a new member of an emerging subgroup of serine oligopeptidases. J Biol Chem. 274(37):26149-56, 1999. Download PDF version
• Troeberg L, Morty RE, Pike RN, Lonsdale-Eccles JD, Palmer JT, McKerrow JH, Coetzer TH. Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei. Exp Parasitol. 91(4):349-55, 1999. Download PDF version
• Morty RE, Troeberg L, Pike RN, Jones R, Nickel P, Lonsdale-Eccles JD, Coetzer TH. A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin. FEBS Lett. 433(3):251-6, 1998. Download PDF version
• Troeberg L, Pike RN, Morty RE, Berry RK, Coetzer TH, Lonsdale-Eccles JD. Proteases from Trypanosoma brucei brucei. Purification, characterisation and interactions with host regulatory molecules. Eur J Biochem. 238(3):728-36, 1996. Download PDF version